📃 Paper Title: Testosterone Therapy in Men With Prostate Cancer
🧍 Author: Kaplan
🕒 Year: 2015
📚 Journal: European Urology
🌎 Country: USA
ㅤContext to the study:
What is the evidence between providing teststerone injections and prostate cancer.
ㅤ✅ Take-home message of study:
Use of testosterone does not increase risk of developing prostate cancer nor worsen its severity if previously diagnosed. It can be used safety to treat testosterone deficiency with careful clinical monitoring in men with history of prostatic malignancy.
ㅤ Systematic Review
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Study participants:
1572 Patients from 13 studies on testoerone therapy in men with prostate cancer.
Inclusion Criteria
All publications related to the use of testosterone in men with prostate cancer, treated or otherwise.
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Key study outcomes:
The following is a summary of conclusions made:
Testosterone deficiency is detrimental to health (body composition, metabolic control, psychological and sexual parameters) and has a significant impact on quality of life
Testosterone therapy can mitigate these untoward effects
High levels of endogenous androgen does not increase the risk or severity of prostate cancer
Testosterone therapy does not increase the risk or severity of prostate cancer
Testosterone therapy does not increase the risk of recurrence or progression in treated prostate cancer
The impact of androgen on prostatic cells is subject to a saturation effect.
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Study Limitations:
Does not follow PRISMA in reporting.
No quantitative analysis of data available in literature.
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